Chapter 47 Unrelated Donor Hematopoietic Cell Transplantation
Table 47-1 Common Definitions in Human Leukocyte Antigen Genetics
Term | Definition | Example |
---|---|---|
Allele | Unique sequence of an HLA gene defined by molecular methods | DRB1*04:01 allele is a unique sequence defined as DR4 by serologic methods |
Antigen | Antibody-defined protein | DR4 antigen is a serologically defined protein product of an HLA gene |
Haplotype | HLA genes inherited as a chromosomal unit | HLA-A1, HLA-B8, HLA-DR3 is a common haplotype among white populations |
Genotype | Molecularly defined HLA allele or sequence | Genotypically matched donor and recipient are identical for the HLA alleles at a given HLA gene (e.g., HLA-DRB1*04:01) |
Phenotype | Serologically defined HLA protein or antigen | Phenotypically matched donor and recipient share the same HLA antigen (e.g., HLA-DR4) |
HLA, Human leukocyte antigen.
![image](/wp-content/uploads/2016/06/B9781455776887000475_t0015.png)
GVH, Graft versus host; HVG, host versus graft.
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