Unrelated Donor Hematopoietic Cell Transplantation

Chapter 47 Unrelated Donor Hematopoietic Cell Transplantation

Table 47-1 Common Definitions in Human Leukocyte Antigen Genetics

Term Definition Example
Allele Unique sequence of an HLA gene defined by molecular methods DRB1*04:01 allele is a unique sequence defined as DR4 by serologic methods
Antigen Antibody-defined protein DR4 antigen is a serologically defined protein product of an HLA gene
Haplotype HLA genes inherited as a chromosomal unit HLA-A1, HLA-B8, HLA-DR3 is a common haplotype among white populations
Genotype Molecularly defined HLA allele or sequence Genotypically matched donor and recipient are identical for the HLA alleles at a given HLA gene (e.g., HLA-DRB1*04:01)
Phenotype Serologically defined HLA protein or antigen Phenotypically matched donor and recipient share the same HLA antigen (e.g., HLA-DR4)

HLA, Human leukocyte antigen.

Jun 12, 2016 | Posted by in HEMATOLOGY | Comments Off on Unrelated Donor Hematopoietic Cell Transplantation

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