Transplant/Total Body Irradiation
Background
Define hematopoietic stem cell transplantation (HSCT).
HSCT is a procedure to infuse hematopoietic cells in order to restore normal hematopoiesis and/or to treat cancer.
What is the difference between allogeneic and autologous?
Allogeneic: stem cells from another person
Autologous: stem cells from the affected pt
What is a syngeneic transplant?
A syngeneic transplant uses an identical twin as the donor.
Name 3 sources of stem cells.
Umbilical cord blood, BM, and peripheral blood are 3 sources of stem cells.
What source of stem cells is most often used for transplant?
Most stem cells for transplant are obtained from peripheral blood.
What is a mini-transplant?
A mini-transplant, also known as nonmyeloablative or reduced-intensity transplant, employs less toxic preparatory regimens, targeted to host T cells to facilitate engraftment.
Name 4 malignancies routinely treated with autologous transplant.
Malignancies routinely treated with autologous transplant:
Recurrent Hodgkin Dz
Multiple myeloma
Chemosensitive aggressive non-Hodgkin lymphoma
Refractory testicular cancer
Which type of transplant is associated with a graft vs. tumor effect?
Allogeneic transplants may have graft vs. tumor effect.
Why is there decreased mortality with an autologous transplant in comparison to an allogeneic transplant?
The mortality rate with autologous transplant is lower due to the absence of graft-versus-host disease (GVHD).
What limits the use of allogeneic transplant?
The use of allogeneic transplant is limited by availability of donors.
What is the most important risk associated with autologous transplant?
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