Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

Chapter 59 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome



Keith R. McCrae, J. Evan Sadler, Douglas B. Cines



Table 59-1 Proposed Classification Scheme for Thrombotic Microangiopathies









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Jun 12, 2016 | Posted by in HEMATOLOGY | Comments Off on Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome

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ADVANCED UNDERSTANDING OF ETIOLOGY


Infection induced


Shiga and verocytotoxin (Shiga-like toxin)–producing bacteria

Streptococcus pneumoniae

Disorders of complement regulation


Genetic disorders of complement regulation

Acquired disorders of complement regulation, for example anti-FH antibody

ADAMTS13 abnormalities


ADAMTS13 deficiency secondary to mutations

Autoantibodies against ADAMTS13

Defective cobalamine metabolism


Quinine induced

ETIOLOGY NOT FULLY UNDERSTOOD