Regulation of Neurocognitive and Neuropsychiatric Function

 

Disease state

Cognitive function

Psychopathology

Coping Strategies and illness perceptions

Cushing’s syndrome or Cushing’s disease

Active or uncontrolled disease

Impaired

Major depression, anxiety disorders, acute psychosis, delirium

Not studied

Long-term remission

Subtle cognitive impairments

Maladaptive personality traits, especially: Apathy, irritability, anxiety, negative affect, and lack of positive affect

Less effective coping

More negative illness perceptions

Adrenal insufficiency

Disease manifestation

Not studied

Depression, anxiety

During Addisonian crisis: agitation, delirium, visual- and auditory hallucinations

Not studied

After long-term glucocorticoid replacement

Mild cognitive deficits

Irritability and somatic arousal, strong relation with daily hydrocortisone dose

Less effective coping

More negative illness perceptions, associated with concerns and stronger beliefs about the necessity of hydrocortisone intake

Glucocorticoid use
 
Not studied

Depression

Delirium/confusion/disorientation

Mania

Panic disorder

Suicidal behaviour

Not studied


Cognitive function: various tests, which evaluated global cognitive functioning, memory, and executive functioning

Psychopathology: evaluated using questionaires, focussing on frequently occurring psychiatric symptoms in somatic illness

Coping strategies: compared with the normal population

Illness perceptions: evaluated using the Illness Perception Questionnaire (IPQ) Revised. Illness perceptions showed a strong correlation with quality of life





References



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Jun 27, 2017 | Posted by in ENDOCRINOLOGY | Comments Off on Regulation of Neurocognitive and Neuropsychiatric Function

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