Chapter 5 • Regulated cell death can occur via extrinsic apoptosis, intrinsic apoptosis, or regulated necrosis. Autophagy operates as a bona fide cell death mechanism in a few (mostly developmental) settings. • Oncogenesis results from multiple molecular alterations, one of which frequently impairs the ability of cancer cells to die in response to exogenous or endogenous signals. • Several oncoproteins and oncosuppressor proteins regulate the molecular machinery for apoptotic or necrotic cell death either directly or in an indirect fashion. • Targeting deregulated cell death signaling pathways in cancer is a clinical reality and underlies promising approaches for the development of novel anticancer regimens. 1. Which of the following molecular alterations may be common among patients with lymphoma?
Pathophysiology of Cancer Cell Death
Summary of Key Points
