| Usually susceptible | Variable | Usually resistant |
|---|---|---|
| Penicillin and derivatives Ampicillin (± sulbactam) Amoxicillin (± clavulanate) Ticarcillin (± clavulanate) Piperacillin (± tazobactam) | Semisynthetic penicillins Oxacillin Dicloxacillin Cloxacillin Nafcillin | Vancomycin Clindamycin Erythromycin (oral) |
| Second- and third-generation cephalosporinsa Cefuroxime Cefotetan Cefoxitin Cefiximeb Cefprozilb Loracarbefb Cefpodoximeb Ceftriaxone Ceftizoxime Cefotaxime Ceftazidime Advanced-generation cephalosporins Ceftarolineb | Cefaclor First-generation cephalosporins Cephalexin Cefazolin Cephradine Cefadroxil Erythromycin (IV) Aminoglycosides Gentamicin Tobramycin Amikacin | |
| Ciprofloxacinb | ||
| Chloramphenicol | ||
| Trimethoprim–sulfamethoxazoleb | ||
| Aztreonam | ||
| Imipenem | ||
| Tetracycline | ||
| Doxycycline |
Table 146.2 Doses of the most efficacious agents for treatment of Pasteurella multocida
| Agent | Oral | Parenteral |
|---|---|---|
| Penicillin V | 500–750 mg q6h | |
| Penicillin G | 10 million to 20 million units/d divided q4h | |
| Amoxicillin (± clavulanate) | 250–500 mg q6h | |
| Ampicillin | 250–500 mg q6h | 1–2 g q4–6h |
| Ampicillin–sulbactam | 1.5–3 g q6h | |
| Ticarcillin–clavulanate | 3.1 g q4–8h | |
| Piperacillin | 3–4 g q4–6h | |
| Cefuroxime | 250–500 g q12h | 750 mg–1.5 g q8h |
| Cefoxitin | 1–2 g q4–8h | |
| Cefotaxime | 1–2 g q4–8h | |
| Ceftriaxone | 1–2 g q24h | |
| Ciprofloxacin | 500–750 mg q12h | 400 mg q12h |
| TMP–SMX | 160 mg TMP (1 DS tab) BID | 10 mg/kg/d TMP divided q6–12h |
| Aztreonam | 500 mg–2 g q6–12h | |
| Imipenem | 500 mg–1 g q6–8h | |
| Meropenem | 2 g q8h | |
| Tetracycline | 250–500 mg q6h | 500 mg–1 g q12h |
| Doxycycline | 100–200 mg q12h | 100–200 mg q12h |
| Chloramphenicol | 12.5–25 mg/kg q6h | 12.5–25 mg/kg q6h |
Abbreviations: TMP–SMX = trimethoprim–sulfamethoxazole; DS = double strength.
While Pasteurella is universally resistant to clindamycin and vancomycin, most strains are resistant to erythromycin, and only moderately sensitive to aminoglycosides.
Prophylactic antibiotic
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