Single agent

1. β-lactam–β-lactamase inhibitor (piperacillin–tazobactamb,c)

2. Moxifloxacinb,c,d,e,f

3. Carbapenem (imipenemb,c, meropenemc, doripenemc, or ertapenemg)d

4. Tigecyclineb,f,h

5. Cefazolin, cefuroxime, ceftriaxone, or cefotaxime plus metronidazole

6. A third- or fourth-generation cephalosporin (ceftazidimec or cefepimec) plus metronidazole

7. Levofloxacind,e,for ciprofloxacinc,d,e,fplus metronidazole

8. Aztreonamc,f,iplus vancomycin plus metronidazoleb

a These regimens should be adjusted based on the results of culture and susceptibility testing.

b Empiric regimens with activity against Enterococcus faecalis are preferred for severe or nosocomial infections.

c Antipseudomonal

d The carbapenems and often fluoroquinolones, but not third-generation cephalosporins or β-lactam–β-lactamase inhibitor combinations, are active against ampC β-lactamase-producing and extended-spectrum β-lactamase (ESBL)-producing aerobic–facultative gram-negative bacilli.

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Jun 18, 2016 | Posted by in INFECTIOUS DISEASE | Comments Off on Peritonitis

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