Orbital and Intraocular Primary Eye Lymphomas
Background
Under what type of lymphomas are intraocular/orbital lymphomas classified?
Intraocular/orbital lymphomas are classified as non-Hodgkin lymphomas (B-cell histology > T-cell histology).
What is the median age of onset? What are the 2 main types of eye lymphoma?
The median age of onset is 50–60 yrs (females > males). The 2 main types are intraocular and orbital/ocular adnexa lymphoma.
What % of pts with primary intraocular lymphomas develop CNS Dz within 3 yrs?
60%–80% of pts with intraocular lymphomas develop CNS Dz.
What % of pts with primary CNS lymphomas develop intraocular involvement?
25% of pts with primary CNS lymphoma develop intraocular involvement.
What is the recurrence rate after Tx of intraocular lymphomas?
The recurrence rate after Tx is ~50%.
Intraocular lymphoma is bilat in what % of pts? How about orbital/adnexa lymphoma?
Intraocular: 80%
Orbital: 20%
What is a common chromosomal trans-location in intraocular lymphoma? What % of pts have this translocation?
t(14:18) is a common translocation in intraocular lymphoma. 56% of pts have this translocation.
Ocular lymphoma cells are usually positive for which 2 important immunohistochemical markers?
Ocular lymphomas usually stain positive for CD20 and bcl-2.
What type of lymphoma accounts for most lymphomas of the ocular adnexa?
MALT lymphoma accounts for most lymphomas of the ocular adnexa.
Which ocular lymphoma has a male predominance and is associated with mycosis fungoides?
Ocular lymphoma of T-cell histology occurs predominantly in males and is associated with mycosis fungoides.
With what infectious agent has orbital MALT been associated? What site is often involved?
Chlamydia psittaci has been associated with orbital MALT lymphomas. The lacrimal gland is often involved.
Lymphoma of what orbital structure has a high propensity for LN spread?
Lacrimal gland lymphoma
Related posts:
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
