Meningioma
Background
What % of all primary intracranial tumors do meningiomas account for in adults?
15%–20% (2nd only to gliomas). Meningioma is the most common benign 1° CNS tumor.
What are the age and gender predilection for meningiomas?
Meningiomas appear late in life (with a peak in the 7th decade). Females are more commonly affected than males (2:1).
What are some risk factors for meningiomas?
Prior RT (RR 10), NF-2, and HRT in women (RR 2)
Which protein is defective in NF-2, and to what else does NF-2 predispose?
Merlin; bilat acoustic neuromas/ependymomas and juvenile subcapsular cataracts
What histologic features can be seen in meningiomas?
Psammoma bodies and calcifications
What % of grade I meningiomas express progesterone receptors?
75% of grade I meningiomas express progesterone receptors.
Name 5 negative prognostic factors for meningiomas.
Negative prognostic factors for meningiomas:
High grade
Young age
Chromosome alterations
Poor performance status
STR
Workup/Staging
What is the grade classification of meningiomas?
WHO grade I (benign), grade II (atypical), and grade III (anaplastic/malignant)
Of grade I meningiomas, which histologic subtype is most aggressive?
The angioblastic subtype is the most aggressive grade I meningioma.
What is the OS difference between atypical and anaplastic meningiomas?
Atypical 12 yrs vs. anaplastic 3.3 yrs (Yang SY et al., J Neurol Neurosurg Psych 2007)
What are some prognostic factors identified for anaplastic meningiomas?
Brain invasion, adj RT, extent of resection, and p53 overexpression (Yang SY et al., J Neurol Neurosurg Psych 2007)
What is the most common Sx at presentation for meningiomas?
HA is the most common presenting Sx.
What is the appearance of meningiomas on CT/MRI?
Homogeneously and intensely enhancing mass, +/− dural tail
What % of meningiomas exhibit a dural tail? In what other tumors/lesions can dural tails be seen?
Related posts:
Stay updated, free articles. Join our Telegram channel
Full access? Get Clinical Tree
