Part of “CHAPTER 66 – RARE DISORDERS OF SKELETAL FORMATION AND HOMEOSTASIS“

Idiopathic juvenile osteoporosis is a poorly characterized, heterogeneous condition that almost certainly has a variety of causes.4 A few case reports and small clinical series indicate that the disorder typically presents during late childhood with fracture—especially in the lower limbs and with vertebral collapse—but afterwards improves spontaneously.86 Distinction from OI requires a careful physical examination and family history. Idiopathic juvenile osteoporosis is generally a diagnosis of exclusion; secondary causes of osteopenia in children must always be considered (see Chap. 70).4 No established therapy exists, but dietary deficiencies (e.g., suboptimal calcium intake) should be corrected, and patients should be cautioned against stooping to lift heavy objects or participating in potentially traumatic physical activity. Bisphosphonate therapy is being evaluated.