Part of “CHAPTER 125 – APPETITE“

In the early 1940s, it was demonstrated that bilateral lesions in the ventromedial hypothalamus (VMH) of animals caused hyperphagia and obesity (see Chap. 8 and Chap. 9).1 Some years later it was shown that lesions in the lateral hypothalamus (LH) resulted in aphagia and finally death.2 These results led to the
simplified general concept of the LH as a “feeding center” and the VMH as a “satiety center.”