13 Diseases affecting erythrocytes Microcytic/hypochromic anemia Iron deficiency anemia FIGURE 13–1A Severe iron deficiency anemia (peripheral blood [PB] ×500). FIGURE 13–1B Iron deficiency anemia (PB ×1000). FIGURE 13–1C Iron deficiency anemia (bone marrow [BM] ×1000; showing shaggy cytoplasm). Peripheral blood: Erythrocytes are hypochromic and microcytic; large variation in size; possible thrombocytosis Note: Small lymphocyte depicted for size comparison. Bone marrow: Erythrocyte precursors are smaller and more numerous than normal and have shaggy cytoplasm. There is nuclear cytoplasmic asynchrony, with cytoplasmic maturation lagging behind that of the nucleus. β-thalassemia minor β/β+ β/β0 β/δβ0 β/δβlepore FIGURE 13–2A β-Thalassemia minor (PB ×500). FIGURE 13–2B β-Thalassemia minor (PB ×1000). The presence of basophilic stippling (arrow) is common in thalassemia minor but not in iron deficiency anemia. Peripheral blood: Microcytosis, slight hypochromia, target cells, basophilic stippling β-thalassemia major β0β0 β+β+ β0β+ δβlepore/δβlepore FIGURE 13–3A β-Thalassemia major (PB ×500). FIGURE 13–3B β-Thalassemia major (PB ×1000). Peripheral blood: Marked variation in size and shape, numerous nucleated erythrocytes, microcytes, hypochromia, target cells, basophilic stippling, tear drop cells, schistocytes, polychromasia α-thalassemia* Hemoglobin h −−/−α Peripheral blood: Microcytes, hypochromia, marked poikilocytosis, target cells, polychromasia (see Figure 12-5, C). Hemoglobin bart hydrops fetalis syndrome −−/−− Peripheral blood: Numerous nucleated erythrocytes, marked variation in size, hypochromia, variable polychromasia, macrocytes FIGURE 13–4A Bart hemoglobin (PB ×500). FIGURE 13–4B Bart hemoglobin (PB ×1000). Macrocytosis Nonmegaloblastic FIGURE 13–5A Macrocytic (nonmegaloblastic) (PB ×500). FIGURE 13–5B Macrocytic (nonmegaloblastic) (PB ×1000). Peripheral blood: Round macrocytes, leukocyte and platelet counts usually normal Bone marrow: No megaloblastic changes Associated with: Normal newborn, liver disease, chronic alcoholism Megaloblastic anemia FIGURE 13–6A Megaloblastic anemia (PB ×500). Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Hematopoiesis Precursor lymphoid neoplasms Variations in size and color of erythrocytes Microorganisms Mature lymphoproliferative disorders Variations in shape and distribution of erythrocytes Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Hematology Atlas Jun 12, 2016 | Posted by admin in HEMATOLOGY | Comments Off on Diseases affecting erythrocytes Full access? Get Clinical Tree
13 Diseases affecting erythrocytes Microcytic/hypochromic anemia Iron deficiency anemia FIGURE 13–1A Severe iron deficiency anemia (peripheral blood [PB] ×500). FIGURE 13–1B Iron deficiency anemia (PB ×1000). FIGURE 13–1C Iron deficiency anemia (bone marrow [BM] ×1000; showing shaggy cytoplasm). Peripheral blood: Erythrocytes are hypochromic and microcytic; large variation in size; possible thrombocytosis Note: Small lymphocyte depicted for size comparison. Bone marrow: Erythrocyte precursors are smaller and more numerous than normal and have shaggy cytoplasm. There is nuclear cytoplasmic asynchrony, with cytoplasmic maturation lagging behind that of the nucleus. β-thalassemia minor β/β+ β/β0 β/δβ0 β/δβlepore FIGURE 13–2A β-Thalassemia minor (PB ×500). FIGURE 13–2B β-Thalassemia minor (PB ×1000). The presence of basophilic stippling (arrow) is common in thalassemia minor but not in iron deficiency anemia. Peripheral blood: Microcytosis, slight hypochromia, target cells, basophilic stippling β-thalassemia major β0β0 β+β+ β0β+ δβlepore/δβlepore FIGURE 13–3A β-Thalassemia major (PB ×500). FIGURE 13–3B β-Thalassemia major (PB ×1000). Peripheral blood: Marked variation in size and shape, numerous nucleated erythrocytes, microcytes, hypochromia, target cells, basophilic stippling, tear drop cells, schistocytes, polychromasia α-thalassemia* Hemoglobin h −−/−α Peripheral blood: Microcytes, hypochromia, marked poikilocytosis, target cells, polychromasia (see Figure 12-5, C). Hemoglobin bart hydrops fetalis syndrome −−/−− Peripheral blood: Numerous nucleated erythrocytes, marked variation in size, hypochromia, variable polychromasia, macrocytes FIGURE 13–4A Bart hemoglobin (PB ×500). FIGURE 13–4B Bart hemoglobin (PB ×1000). Macrocytosis Nonmegaloblastic FIGURE 13–5A Macrocytic (nonmegaloblastic) (PB ×500). FIGURE 13–5B Macrocytic (nonmegaloblastic) (PB ×1000). Peripheral blood: Round macrocytes, leukocyte and platelet counts usually normal Bone marrow: No megaloblastic changes Associated with: Normal newborn, liver disease, chronic alcoholism Megaloblastic anemia FIGURE 13–6A Megaloblastic anemia (PB ×500). Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Hematopoiesis Precursor lymphoid neoplasms Variations in size and color of erythrocytes Microorganisms Mature lymphoproliferative disorders Variations in shape and distribution of erythrocytes Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Hematology Atlas Jun 12, 2016 | Posted by admin in HEMATOLOGY | Comments Off on Diseases affecting erythrocytes Full access? Get Clinical Tree
