11 Variations in shape and distribution of erythrocytes Poikilocytosis is a general term for the presence of abnormally shaped red blood cells. In most cases, we have opted to use the more specific name for each abnormally shaped red blood cell in place of the term poikilocytosis. Acanthocyte Spur cell FIGURE 11–1A Acanthocytes. FIGURE 11–1B Acanthocytes. FIGURE 11–1C Acanthocytes; two nucleated red blood cells in field. Description: Erythrocyte with irregularly spaced projections that vary in width, length, and number; usually dense, lacking central pallor Associated with: Severe liver disease, splenectomy, malabsorption, hypothyroidism, vitamin E deficiency, abetalipoproteinemia Schistocyte Schizocyte FIGURE 11–2A Schistocytes. FIGURE 11–2B Schistocytes. FIGURE 11–2C Bite cells. FIGURE 11–2D Blister cells. Color: Red to salmon Shape: Fragmented erythrocytes; many sizes and shapes may be present on a smear; often display pointed extremities Associated with: Microangiopathic hemolytic anemia (hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, disseminated intravascular coagulation), severe burns, renal graft rejection Note: Bite and blister cells are the result of splenic pitting of Heinz bodies (see Figure 12-5, B). These cells are often included in the schistocyte category. Echinocyte Burr cell FIGURE 11–3A Echinocytes/burr cells. FIGURE 11–3B Echinocytes/burr cells. Description: Erythrocyte with short, evenly spaced projections usually with central pallor Associated with: Uremia, pyruvate kinase deficiency, microangiopathic hemolytic anemia, neonates (especially premature), artifact Spherocyte FIGURE 11–4A Spherocytes. FIGURE 11–4B Spherocytes. Color: Darker than surrounding red blood cells Shape: Round; no central pallor zone Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Hematopoiesis Precursor lymphoid neoplasms Variations in size and color of erythrocytes Microorganisms Mature lymphoproliferative disorders Diseases affecting erythrocytes Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Hematology Atlas Jun 12, 2016 | Posted by admin in HEMATOLOGY | Comments Off on Variations in shape and distribution of erythrocytes Full access? Get Clinical Tree
11 Variations in shape and distribution of erythrocytes Poikilocytosis is a general term for the presence of abnormally shaped red blood cells. In most cases, we have opted to use the more specific name for each abnormally shaped red blood cell in place of the term poikilocytosis. Acanthocyte Spur cell FIGURE 11–1A Acanthocytes. FIGURE 11–1B Acanthocytes. FIGURE 11–1C Acanthocytes; two nucleated red blood cells in field. Description: Erythrocyte with irregularly spaced projections that vary in width, length, and number; usually dense, lacking central pallor Associated with: Severe liver disease, splenectomy, malabsorption, hypothyroidism, vitamin E deficiency, abetalipoproteinemia Schistocyte Schizocyte FIGURE 11–2A Schistocytes. FIGURE 11–2B Schistocytes. FIGURE 11–2C Bite cells. FIGURE 11–2D Blister cells. Color: Red to salmon Shape: Fragmented erythrocytes; many sizes and shapes may be present on a smear; often display pointed extremities Associated with: Microangiopathic hemolytic anemia (hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, disseminated intravascular coagulation), severe burns, renal graft rejection Note: Bite and blister cells are the result of splenic pitting of Heinz bodies (see Figure 12-5, B). These cells are often included in the schistocyte category. Echinocyte Burr cell FIGURE 11–3A Echinocytes/burr cells. FIGURE 11–3B Echinocytes/burr cells. Description: Erythrocyte with short, evenly spaced projections usually with central pallor Associated with: Uremia, pyruvate kinase deficiency, microangiopathic hemolytic anemia, neonates (especially premature), artifact Spherocyte FIGURE 11–4A Spherocytes. FIGURE 11–4B Spherocytes. Color: Darker than surrounding red blood cells Shape: Round; no central pallor zone Only gold members can continue reading. Log In or Register to continue Share this:Click to share on Twitter (Opens in new window)Click to share on Facebook (Opens in new window) Related Related posts: Hematopoiesis Precursor lymphoid neoplasms Variations in size and color of erythrocytes Microorganisms Mature lymphoproliferative disorders Diseases affecting erythrocytes Stay updated, free articles. Join our Telegram channel Join Tags: Clinical Hematology Atlas Jun 12, 2016 | Posted by admin in HEMATOLOGY | Comments Off on Variations in shape and distribution of erythrocytes Full access? Get Clinical Tree
