Chapter 82 • Renal cell carcinoma (RCC) accounts for 3% of malignancies in adults. • Cigarette smoking (in more than 20% of cases) and obesity (in more than 30%) are established causal factors for RCC. • Four percent of cases of RCC arise from hereditary syndromes. • Different subtypes of RCC are characterized by distinct clinical behavior, genetic abnormalities, and molecular signatures. • Clear cell RCC is the most common histologic subtype, representing approximately 70% of all sporadic RCCs. • The von Hippel-Lindau tumor suppressor gene is genetically and epigenetically altered in more than 75% of sporadic cases of clear cell RCC. • Prognosis for RCC is dependent on tumor histologic type, grade, and stage. • Nephron-sparing surgery has become the gold standard, when feasible. • Follow-up guidelines for resected RCC include history, physical examination, periodic metabolic panels, and abdominal and chest computed tomography (CT) studies 4 to 6 months after surgery.
Cancer of the Kidney
Summary of Key Points
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Cancer of the Kidney
