Biological Tumor Markers












































































































































































Tumor Marker Diagnostic Significance Normal Values
HORMONES
Beta-human chorionic gonadotropin (beta-hCG) in serum Choriocarcinoma 5 mIU/ml
Hepatoblastoma
Catecholamines urinary VMA/HVA Neuroblastoma Appendix 1 , Table A1.34
Plasma and urinary catecholamines and urinary metanephrine and VMA Pheochromocytoma
Testosterone serum Leydig cell tumor (testis) DOM
Sertoli–Leydig cell (ovary)
Estrogen serum Granulosa cell tumor (ovary) DOM
Sertoli cell tumor (testis)
Cortisol, aldosterone, testosterone and estrogen serum Adrenal hyperplasia
Adrenal adenoma
DOM
Adrenal carcinoma
Ectopic adrenal rests (liver, testis, ovary)
Thyrocalcitonin serum Medullary (C-cell) thyroid carcinoma DOM
T3, T4 serum Hyperthyroidism Appendix 1 , Table A1.36
Thyroid adenoma
Thyroid carcinoma
Parathormone serum Parathyroid hyperplasia DOM
Parathyroid adenoma
Parathyroid carcinoma
Hepatoblastoma
Vasoactive intestinal peptide (VIP) Neuroblastoma <75 pg/ml
Vipoma
Renin serum Wilms’ tumor DOM
Erythropoietin serum Wilms’ tumor Appendix 1 , Table A1.17
Adrenal carcinoma
Renal carcinoma
Hepatoma
ENZYMES
Neurone-specific enolase in serum Neuroblastoma 15 ng/ml
Primitive neuroectodermal tumors
Medulloblastoma
Lactic dehydrogenase (LDH) in serum Acute leukemias 297–537 units/l (depending on laboratory)
Non-Hodgkin’s lymphoma
Neuroblastoma
Ewing’s sarcoma
Osteosarcoma
Germ cell tumor
SPECIFIC PROTEINS
Immunoglobulins Multiple myeloma and other gammopathies See reference values in Appendix 1
Cytokines Acute lymphoblastic leukemia
Soluble interleukin-2 receptor (SIL-2R) in serum Non-Hodgkin’s lymphoma
Hodgkin’s disease
Hemophagocytic histiocytic syndrome
MUCINS AND OTHER GLYCOPROTEINS
CA 125 Ovarian cancer <35 units/ml
CA 19–9 Colon cancer, pancreatic cancer ~37 units/ml (for investigation use only)
CA 15–3 Breast cancer <31 units/ml
OTHER TUMOR MARKERS
5-Hydroxyindoleacetic acid in urine (5-HIAA) Carcinoid tumor 24 h urine: 2–8 mg/dl
Neopterins in urine Non-Hodgkin lymphoma 7–150 μg/l
Hemophagocytic lymphohistiocytosis
Ferritin Neuroblastoma 6 months–15 years: 12–113 ng/ml; 15–49 years: 12–156 ng/ml
Hodgkin disease
Hepatocellular carcinoma
Germ cell tumor

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Jul 3, 2019 | Posted by in HEMATOLOGY | Comments Off on Biological Tumor Markers
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