Aplastic Anemia

Chapter 4 Aplastic Anemia

Neal S. Young, Jaroslaw P. Maciejewski

Table 4-1 Differential Diagnosis of Pancytopenia

Pancytopenia With Hypocellular Bone Marrow
Acquired aplastic anemia Inherited aplastic anemia (Fanconi anemia and others) Some myelodysplasia syndromes Rare aleukemic leukemia (acute myeloid leukemia) Some acute lymphoblastic leukemias Rare lymphomas of bone marrow
Pancytopenia With Cellular Bone Marrow
Primary bone marrow diseases Myelodysplasia syndromes Paroxysmal nocturnal hemoglobinuria Myelofibrosis Some aleukemic leukemias Myelophthisis Bone marrow lymphoma Hairy cell leukemia Secondary to systemic diseases Systemic lupus erythematosus, Sjögren syndrome Hypersplenism Vitamin B₁₂, folate deficiency (familial defect) Overwhelming infection Alcohol Brucellosis Ehrlichiosis Sarcoidosis Tuberculosis and atypical mycobacteria
Hypocellular Bone Marrow ± Cytopenia
Q fever Legionnaires disease Mycobacteria Tuberculosis * Anorexia nervosa, starvation Hypothyroidism

^*Pancytopenia in tuberculosis only rarely is associated with a hypocellular bone marrow at biopsy or autopsy. Marrow failure in the setting of tuberculosis is almost always fatal; exceptional patients probably had underlying myelodysplasia or acute leukemia.

Table 4-2 A Classification of Aplastic Anemia

Acquired Aplastic Anemia
Secondary aplastic anemia Irradiation Drugs and chemicals Regular effects Cytotoxic agents Benzene Idiosyncratic reactions Chloramphenicol Nonsteroidal antiinflammatory drugs Antiepileptics Gold Other drugs and chemicals Viruses Epstein-Barr virus (infectious mononucleosis) Hepatitis virus (non-A, non-B, non-C, non-G hepatitis) Parvovirus (transient aplastic crisis, some pure red blood cell aplasia) Human immunodeficiency virus (acquired immunodeficiency syndrome) Immune diseases Eosinophilic fasciitis Hyperimmunoglobulinemia Thymoma and thymic carcinoma Graft-versus-host disease in immunodeficiency Paroxysmal nocturnal hemoglobinuria Pregnancy Idiopathic aplastic anemia
Inherited Aplastic Anemia
Fanconi anemia Dyskeratosis congenita Shwachman-Diamond syndrome Reticular dysgenesis Amegakaryocytic thrombocytopenia Familial aplastic anemias Only gold members can continue reading. Log In or Register to continue Related posts: Heme Biosynthesis and Its Disorders: Sideroblastic Anemia Infectious Mononucleosis and Other Epstein-Barr Virus–Associated Diseases: Part 2 Thrombotic Thrombocytopenic Purpura and the Hemolytic Uremic Syndrome Infectious Mononucleosis and Other Epstein-Barr Virus–Associated Diseases: Part 1 Disorders of Phagocyte Function Inherited Forms of Bone Marrow Failure Stay updated, free articles. Join our Telegram channel Tags: Hematology Diagnosis and Treatment Jun 12, 2016 \| Posted by admin in HEMATOLOGY \| Comments Off on Aplastic Anemia Full access? Get Clinical Tree Get Clinical Tree app for offline access Get Clinical Tree app for offline access