Composition
Product name
FDA-approved dosage
Vaginal creams
17β-estradiol
Estrace vaginal cream®
Initial: 2–4 g/day for 1–2 weeks
maintenance: 1 g/1–3 times/week
Conjugated estrogens
Premarin vaginal cream®
For VVA: 0.5–2 g/day for 21 day then off 7 d
for dyspareunia: 0.5 g/d for 21 day then off 7 day, or twice/week
Estrone
Estragyn vaginal cream®
2–4 g/day; intended for short-term use; progestogen recommended
Vaginal rings
17β-estradiol
Estring®
Device containing 2 mg releases approximately 7.5 µg/day for 90 day
Estradiol acetate
Femring®
Device containing 12.4 mg or 24.8 mg estradiol acetate releases 0.05 mg/day or 0.1 mg/day estradiol for 90 days
Vaginal tablet
Estradiol hemihydrate
Vagifem®
Initial: 1 tablet/day for 2 weeks