Vaccination of Healthy Adults



Vaccination of Healthy Adults


Waseem Ahmad

Paras Patel



INTRODUCTION

An effective means of preventing infectious diseases is immunization, the act of artificially inducing immunity or providing protection from disease; it can be active or passive. The goal of active immunization of a vaccine or toxoid is to stimulate the host to produce a primary immune response. Passive immunization involves administration of antibodies.

Vaccines may be live attenuated organisms, dead/inactivated organisms, or purified products derived from them. Commonly employed killed vaccines include influenza vaccine, cholera vaccine, bubonic plague vaccine, inactivated polio vaccine, hepatitis A vaccine, and rabies vaccine. Major live attenuated vaccines include influenza vaccine (FluMist), yellow fever, measles, rubella, mumps, varicella, typhoid and BCG.

CDC recommends routine vaccination to prevent 17 vaccine-preventable diseases that occur in infants, children, adolescents, or adults. Optimal response to a vaccine depends on multiple factors, including the type of vaccine, age of the recipient, and immune status of the recipient. Certain products, including inactivated vaccines, toxoids, recombinant subunit vaccines, polysaccharide conjugate vaccines, and live vaccines, require ≥2 doses to elicit an adequate antibody response. Tetanus and diphtheria toxoids require booster doses to maintain protective antibody concentrations. See Table 59-1 for a summary of recommendations.


SPECIFIC KEY VACCINES


Influenza Vaccination



  • Annual vaccination against influenza is recommended for all persons aged 6 months and older, including all adults.


  • Healthy, nonpregnant adults aged <50 years without high-risk medical conditions can receive either intranasally administered live, attenuated influenza vaccine (Flu-Mist) or inactivated vaccine.


  • Other persons should receive the inactivated vaccine. Adults aged 65 years and older can receive the standard influenza vaccine or the high-dose (Fluzone) influenza vaccine.


Tetanus, Diphtheria, and Acellular Pertussis Vaccination



  • Administer a one-time dose of tetanus, diphtheria, and acellular pertussis (Td/Tdap) to adults aged <65 years who have not received Tdap previously or for whom vaccine status is unknown to replace one of the 10-year Td boosters and as soon as feasible to all (i) postpartum women, (ii) close contacts of infants younger than age 12 months (e.g., grandparents and child-care providers), and (iii) healthcare personnel with direct patient contact.










    Table 59-1 Vaccines for Adults




























































    Vaccine


    Doses


    Recommendation


    Comment


    Measles-mumpsrubella (MMR)


    One or two doses


    High-risk groups such as college students, healthcare workers, and international travelers should receive two doses; others should receive one dose.


    Adults born before 1956 have innate immunity and do not require vaccine.


    Tetanus-diphtheria and tetanus-reduced diphtheria-acellular pertussis (Tdap)


    Td every 10 years


    All adults should receive a Td every 10 years after completion of primary series.


    Adults ages 19 to 64 should receive a single dose of Tdap in place of a Td booster if their last dose of Td was 10 years previously or earlier.


    Influenza


    One dose every year


    All adults every year


    Allergic hypersensitivity to egg proteins is a contraindication for vaccine.


    Pneumococcal vaccine, polysaccharidea


    One or two doses




    • All adults age ≥65 years of age



    • Adults 19 through 64 years of age who are smokers or have asthma or any long-term health conditions



    • Residents of nursing homes or long-term care facilities


    A second dose is recommended for people 65 years and older who got their first dose when they were younger than 65 and it has been 5 or more years since the first dose.


    Varicella


    Two doses 28 days apart


    High-risk adults who never had chickenpox or not received chickenpox vaccine


    Healthcare professionals, teachers, child-care workers, residents and staff in the long-term care facilities, nonpregnant women of childbearing age, college students


    Zoster vaccine


    Single dose


    Adults 60 years old or older, whether or not the patient reported a prior episode of shingles. Persons with chronic medical conditions may be vaccinated unless a contraindication or precaution exists for their condition.


    Not if allergic to neomycin and gelatin, immunocompromised pts, pregnant women, active untreated tuberculosis (until resolved), children, or adolescents


    Hepatitis A


    Two-dose series


    Adults in high-risk groups


    High-risk group that includes international travelers, residents of communities with high rates of infection (Native Americans, Alaskan natives, and Pacific Islanders), homosexual and bisexual men, injection-drug users, persons with chronic liver disease, and food handlers


    Hepatitis B


    Three-dose series at 0, 1, and 6 months


    Universal infant vaccination and catch-up vaccination of nonimmune older children, adolescents, and high-risk individuals


    High-risk groups include healthcare workers, residents and staff of long-term care facilities or prisons, homosexual or bisexual men or heterosexuals with multiple partners, injection-drug users, recipients of clotting factor concentrates, household or sexual contacts of HBV carriers.


    HPV vaccine


    Three doses series at 0, 1, and 6 months


    For girls ages 11-12 years, with catch-up vaccination for girls and women ages 13-26 years


    Advisory Committee on Immunization Practices (ACIP) provided guidance that HPV4 may be given to males aged 9 through 26 years to reduce their likelihood of acquiring genital warts; ACIP does not recommend HPV4 for routine use among males.


    Meningococcal vaccine


    Two doses. The first dose at 11 or 12 years of age, with a booster dose at age 16


    Adolescents 11 through 18 years of age, college freshmen living in dormitories, microbiologists who are routinely exposed to isolates of Neisseria meningitidis, military recruits, people who have terminal complement component deficiencies and have anatomic or functional asplenia


    Covers serogroups A, C, Y, and W-135, but not B


    a The FDA approved a 13-valent, conjugate pneumococcal vaccine for adults >50 in December 2011 but this has not been added to the vaccine schedule to date.

    Only gold members can continue reading. Log In or Register to continue

    Stay updated, free articles. Join our Telegram channel

Jun 22, 2016 | Posted by in INFECTIOUS DISEASE | Comments Off on Vaccination of Healthy Adults

Full access? Get Clinical Tree

Get Clinical Tree app for offline access