Translational and Post-translational Control of Leptin Production by Fat Cells

Fig. 10.1

mTORC1 couples leptin secretion to the adipocyte size. Insulin and nutrients activate leptin biosynthesis via the mTORC1-mediated pathway that also promotes storage of triglycerides and increases the size of the cell. De novo synthesized leptin molecules are partitioned between constitutive and regulated secretion and immediate degradation

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