Author
Method
Patients (n)
Tumor size (cm)
Overall survival
p
1 y (%)
3 y (%)
5 y (%)
Vivarelli (2004) [17]
Surgery
79
n.a.
83
65
n.a.
0.002
RFA
79
n.a.
78
33
n.a.
Hong (2005) [16]
Surgery
93
2.5 ± 0.8
97.9
83.9
n.a.
0.240
RFA
55
2.4 ± 0.6
100
72.7
n.a.
Montorosi (2005) [31]
Surgery
40
n.a.
84
73
n.a.
0.139
RFA
58
n.a.
85
61
n.a.
Cho (2005) [9]
Surgery
61
3.4 ± 1
98.3
77.4
n.a.
0.77
RFA
99
3.1 ± 0.8
95.8
80.0
n.a.
Ogihara (2005) [32]
Surgery
47
7.4 ± 5.2
75
65
31
n.s.
RFA
40
4.6 ± 2.9
78
58
39
Lü (2006) [5]
Surgery
54
n.a.
91.3
86.4
n.a.
0.808
RFA
51
n.a.
93.5
87.1
n.a.
Chen (2006)a [4]
Surgery
90
n.a.
93.3
73.4
n.a.
n.s.
RFA
90
n.a.
94.4
68.6
n.a.
Lupo (2007) [15]
Surgery
42
4 (3–5)
91
57
43
0.824
RFA
60
3.65 (3–5)
96
53
32
Takahashi (2007) [12]
Surgery
53
2.5 (1–5)
n.a.
n.a.
70.4
0.561
RFA
171
2.1 (0.7–4.8)
n.a.
n.a.
76.8
Guglielmi (2008) [18]
Surgery
91
n.a.
84
64
48
0.01
RFA
109
n.a.
83
42
20
Abu-Hilal (2008) [33]
Surgery
34
3.8 (1.3–5.0)
91
n.a.
56
0.302
RFA
34
3 (2–5)
83
n.a.
57
Hiraoka (2008) [10]
Surgery
59
2.27 ± 0.55
98.1
91.4
59.4
n.s.
RFA
105
1.98 ± 0.52
95.1
87.8
59.3
Huang (2010)a [6]
Surgery
115
n.a.
98.3
92.2
75.5
0.001
RFA
115
n.a.
87
69.6
54.8
Kobayashi (2009) [11]
Surgery
199
2 (0.9–3.0)
96.9
90.3
79
n.s.
RFA
209
1.8 (0.8–3.0)
99
87.4
74.8
Ueno (2009) [14]
Surgery
123
2.7 ± 0.1
99
92
80
0.06
RFA
155
2.0 ± 0.1
98
92
63
Santambrogio (2009)a [13]
Surgery
78
2.87 ± 1.21
93
85
54
0.163
RFA
74
2.66 ± 1.06
88
66
41
Nanashima (2010) [34]
Surgery
144
n.a.
n.a.
77
57
n.a.
RFA
56
n.a.
n.a.
59
51
Nishikawa (2011) [35]
Surgery
69
2.68 ± 0.49
100
81.4
75.6
0.259
RFA
162
1.99 ± 0.62
95.4
79.6
63.1
Hung (2011) [36]
Surgery
229
2.88 ± 1.06
97.3
88.2
79.3
0.009
RFA
190
2.37 ± 0.92
96.6
77.3
67.4
Wang (2012) [37]
Surgery
52
Very early stage
98
98
91.5
0.298
RFA
91
96.7
89.3
72
Wang (2012) [37]
Surgery
208
Early stage
96.1
87.8
77.2
0.088
RFA
254
91.6
73.5
57.4
Feng (2012)a [38]
Surgery
84
2.6 ± 0.8
96
87.6
74.8
0.342
RFA
84
2.4 ± 0.6
93.1
83.1
67.2
Peng (2012) [39]
Surgery
74
1.1 ± 0.5
90.5
70.9
62.1
0.048
RFA
71
1.2 ± 0.6
98.5
87.7
71.9
Table 10.2
Summary of comparative studies on RF ablation in combination with embolization vs. resection in HCC
Author | Method | Patients (n) | Tumor size (cm) | Overall survival | p | ||
|---|---|---|---|---|---|---|---|
1 y (%) | 3 y (%) | 5 y (%) | |||||
Maluccio (2005) [21] | Surgery | 40 | 4.6 (1.8–7) | 97 | 77 | 56 | 0.200 |
RFA & TACE | 33 | 4 (1.7–7) | 81 | 70 | 58 | ||
Yamakado (2008) [22] | Surgery | 62 | 2.7 ± 1.1 | 97 | 93 | 81 | 0.870 |
RFA & TACE | 104 | 2.5 ± 0.8 | 98 | 94 | 75 | ||
Kagawa (2010) [40] | Surgery | 55 | 2.8 (1–5) | 92.5 | 82.7 | 76.9 | 0.788 |
RFA & TACE | 62 | 2.4 (0.8–5) | 100 | 94.8 | 64.6 | ||
Tashiro (2011) [41] | Surgery | 199 | 2.1 ± 0.63 | 95.6 | 90.9 | 76 | 0.11 |
RFA & TACE | 87 (69 TACE) | 1.8 ± 0.52 | 97.6 | 81.4 | 71 | ||
Table 10.3
Summary of studies of RF ablation in colorectal liver metastases
Author | Method | Patients (n) | Tumor size (cm) | Overall survival | p | Median survival | ||
|---|---|---|---|---|---|---|---|---|
2 y (%) | 3 y (%) | 5 y (%) | ||||||
Orshowo (2003) [42] | Surgery | 20 | 4 (2–7) | n.a. | 55.4 | n.a. | n.s. | 41 |
RFA | 25 | 3 (1–10) | n.a. | 52.6 | n.a. | 37 | ||
Abdalla (2004) [43] | Surgery | 190 | n.a. | n.a. | 73 | 58 | 0.0001 | n.a. |
Surgery + RFA | 101 | n.a. | n.a. | 43 | n.a. | n.a. | ||
RFA | 57 | 2.5 | n.a. | 37 | n.a. | n.a. | ||
Aloia (2006) [44] | Surgery | 150 | 3 (1–7) | n.a. | 79 | 71 | 0.001 | n.a. |
RFA | 30 | n.a. | 57 | 27 | n.a. | |||
Park (2008) [45] | Surgery | 59 | 3.1 (0.5–8) | n.a. | n.a. | 48 | 0.0002 | 56 |
RFA | 30 | 2 (0.6–4) | n.a. | n.a. | 19
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