Radiation Therapy in the Treatment of Hematologic Malignancies

Chapter 23 Radiation Therapy in the Treatment of Hematologic Malignancies



Andrea K. Ng, Peter M. Mauch



Preferred Treatment for Early-Stage Non-Hodgkin Lymphoma



Early-Stage Diffuse Large B-Cell Lymphoma Treated With Combined Modality Therapy



Use of Involved Fields




• After a complete remission achieved with six to eight cycles of CHOP or R-CHOP: 36 Gy if initial bulky disease; 30 Gy for the remainder of patients


• After three to four cycles of CHOP or R-CHOP: 35 to 40 Gy


• After a partial remission: 40 Gy



Early-Stage Follicular Grade 1 and 2 Lymphoma



Use of Involved or Regional Fields


Carefully planned radiation therapy to limited fields with modest doses can significantly reduce the risk for significant damage to the marrow reserve, the risk for developing a treatment-related malignancy, and the risk for long-term toxicity to other normal tissues such as the salivary glands, lungs, heart, kidneys, and bowel.

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Jun 12, 2016 | Posted by in HEMATOLOGY | Comments Off on Radiation Therapy in the Treatment of Hematologic Malignancies

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