Prophylactic gastrostomy tube during chemoradiation for head and neck cancer decreases weight loss but increases rate of tube use beyond six months





Highlights





  • Omitting prophylactic PEG and younger age associated with increased weight loss.



  • Higher risk of feeding tube duration with prophylactic PEG and older patients.



  • Prophylactic PEG did not produce a significant change in global health score.



Abstract


Importance


The role of prophylactic percutaneous endoscopic gastrostomy (PEG) tube placement in head and neck cancer (HNC) patients treated with chemoradiation remains controversial and varies by center.


Objective


To evaluate the impact of prophylactic PEG tube placement in patients undergoing chemoradiation for HNC PEG tube use for more than 6 months and weight loss.


Design, Setting, and Participants


This single-institution retrospective study included 502 patients with head and neck cancer.


Exposures


Concurrent Chemoradiation (CCRT) and prophylactic PEG tube placement.


Main Outcomes and Measures


Univariate analyses were performed to determine risk factors for long term PEG tube and weight loss. Outcomes that were significantly associated with prophylactic PEG were selected for a multivariate analysis. The Kaplan-Meier method was used to estimate survival and the time to PEG removal, with comparisons between groups analyzed by log-rank tests. The global health status score from the EORTC QLQ30 was utilized to assess impact on quality of life.


Results


Significantly higher weight loss was seen with the following variables: 1) omitting prophylactic PEG tube (p < 0.00001), 2) younger age (p = 0.0032), and 3) adjuvant CCRT (p = 0.0005). There was significantly higher risk of feeding tube duration longer than 6 months in those who: received prophylactic PEG tube (p < 0.0001) and were older than the median age of 60.8 years (p = 0.0165) on multivariate analysis. Prophylactic PEG tube was not associated with improved global health status, overall survival, or progression-free survival on univariate analysis.


Conclusions and Relevance


Prophylactic feeding tubes significantly decreased weight loss during treatment. Prophylactic PEG tube and older than median age was significantly associated with higher risk of feeding tube duration longer than 6 months.


Introduction


Head and neck cancer (HNC) management involves a multidisciplinary approach involving surgery, chemotherapy, and radiation therapy . Concurrent chemotherapy with radiation has been shown to increase both local control and survival in locally advanced head and neck cancer .


Concurrent chemoradiation is associated with increased acute and late toxicity . Mucositis from concurrent chemoradiation can result in objective swallowing dysfunction for HNC patients . In some patients, swallowing dysfunction does not resolve with mucositis resolution and can lead to dependence on enteral feeding .


Percutaneous endoscopic gastrostomy (PEG) placement provides enteral feeding and necessary nutritional support without the need for oral intake . Multiple factors have been shown to predispose patients to PEG tube placement and extended dependency on PEG tube including concurrent chemotherapy .


Timing and indication for PEG tube varies by center. Prophylactic PEG tube placement occurs prior to the onset of mucositis and swallowing dysfunction from chemoradiation. On-demand PEG placement occurs only if necessitated by symptoms. The optimal timing of PEG tubes (prophylactic) or (on-demand) continues to be debated. Patients with prophylactic PEG placement have significantly less weight loss and fewer hospitalizations. However, data on long term PEG dependance and quality of life (QoL) over time based on prophylactic or on-demand PEG are lacking. We investigated the impact of prophylactic versus on-demand PEG tube placement on long term PEG tube dependance and overall health in patients undergoing chemoradiation of head and neck cancer at single center.


Methods


Our study was approved by the institutional review board. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) reporting guideline was reviewed, and our study follows the guideline. The study was conducted in accordance with the Declaration of Helsinki . A waiver of consent was obtained from the institutional review board of the institution due to the retrospective nature of the study making consent impractical and because contacting patients to obtain consent would pose a greater risk than the waiver.


Patient data was extracted from medical records and stored on a secure REDCap database and subsequently used for statistical analyses. Patients selected underwent chemoradiation, which included concurrent chemoradiotherapy (CCRT: 70 Gy in 33 fractions to involved disease and 56 Gy in 33 fractions to elective neck lymph node volumes with high-dose cisplatin every 3 weeks), surgery + CCRT, and induction chemotherapy (ICT: TPF (docetaxel, cisplatin, fluorouracil) 3 cycles) + CCRT. Radiation therapy details have been previously published . A total of 502 patients fit these criteria. Continuous variables recorded medians, inter-quartile range limits (25th and 75th percentiles), and range (maximum and minimum). Categorical variables were summarized as frequencies and percentage. Cancer sites with less than 30 patients were grouped to the “other” category. A long-term feeding tube was defined as a feeding tube duration longer than 6 months. A prophylactic percutaneous endoscopic gastrotomy (PEG) tube was defined as patients who had a PEG tube and a radiotherapy (RT) start date earlier than 1/1/2011, or patients who had their PEG tube placed before their RT start date. For risk factors, the continuous variables were dichotomized at the median into upper and lower groups. Univariate analyses, such as logistic regression or Cox regression, were performed to determine risk factors for long term PEG tube and weight loss. Outcomes that were significantly associated with prophylactic PEG were selected for a multivariate analysis.


Time to PEG tube removal was defined as the duration from date of PEG placement to documented PEG out date or censored at the last follow-up date. Patients without documented PEG out date were censored at the last follow-up date. The Kaplan-Meier method was used to estimate the time to PEG tube removal, which was compared between acute and late PEG groups using log-rank tests. The proportion of patients who did not receive acute PEG, but received late PEG, was estimated using an exact binomial confidence interval.


The association between prophylactic PEG and longitudinal QoL overall health was assessed. The global health status score from the EORTC QLQ30 was utilized to assess impact on the quality of life . In the analysis we included QoL survey records from RT start to five years. We utilized linear mixed model on the survey to compare the time-averaged overall health using a mixed effect model.


Results


Of the 502 HNC patients examined, median overall survival was 65.8 months (95 % confidence interval (CI) of 45.9–94.3.) Progression free survival, which was measured to be the time from diagnosis to local/distant failure, or death, was 42.5 months (95 % CI of 31.9–64.6.) Prophylactic PEG tube placement did not impact overall (p = 0.237) or progression free survival (p = 0.728). Details of patient demographics can be found in Table 1 . Continuous variables were dichotomized into “higher” and “lower” groups based on the median. Baseline characteristics of patients with and without prophylactic PEG are listed in Table 2 . Median age in our cohort was 60.8 years.



Table 1

Patient Demographics.






















































































































































































































Variable Value Frequency Percentage
Sex Female 119 23.7 %
Male 383 76.3 %
Race African American 49 9.8 %
American Indian 5 1 %
Asian 4 0.8 %
unknown 22 4.4 %
White 422 84.1 %
Smoking Never 100 19.9 %
Former 274 54.6 %
Current 128 25.5 %
Previous/Other Cancer No 400 79.7 %
Yes 100 19.9 %
Unknown 2 0.4 %
Previous Cancer Surgery No 430 85.7 %
Yes 72 14.3 %
Previous Surgery No 90 17.9 %
Yes 412 82.1 %
Previous Radiation No 472 94 %
Yes 30 6 %
Previous Chemotherapy No 477 95 %
Yes 25 5 %
Clinical stage I 7 1.4 %
II 25 5 %
III 98 19.5 %
IV 360 71.7 %
Unknown 12 2.4 %
Site Larynx 112 22.3 %
Lip/oral cavity 82 16.3 %
Other 39 7.8 %
Pharynx 269 53.6 %
Treatment type CCRT 310 61.8 %
CCRT/ND 9 1.8 %
ICT/CCRT 58 11.6 %
Surg/CCRT 125 24.9 %
PEG tube No 21 4.2 %
Yes 481 95.8 %
Prophylactic PEG No 219 43.6 %
Yes 283 56.4 %
Feeding tube long term No 87 17.3 %
Unknown 5 1 %
Yes 410 81.7 %


Table 2

Baseline Characteristics of Patients With and Without Prophylactic PEG.
























































































































































































Variable Value No Yes p-value
Age higher 116 (46.2 %) 135 (53.8 %) 0.2801
lower 103 (41 %) 148 (59 %)
Sex Female 47 (39.5 %) 72 (60.5 %) 0.3411
Male 172 (44.9 %) 211 (55.1 %)
Race Other 16 (27.6 %) 42 (72.4 %) 0.0106
White 194 (46 %) 228 (54 %)
Smoking Never 53 (53 %) 47 (47 %) 0.0798
Former 117 (42.7 %) 157 (57.3 %)
Current 49 (38.3 %) 79 (61.7 %)
Previous/ Other/Current Cancer No 171 (42.8 %) 229 (57.3 %) 0.5742
Yes 46 (46 %) 54 (54 %)
Previous Surgery No 30 (33.3 %) 60 (66.7 %) 0.0345
Yes 189 (45.9 %) 223 (54.1 %)
Previous Radiation No 206 (43.6 %) 266 (56.4 %) 1
Yes 13 (43.3 %) 17 (56.7 %)
Previous Chemotherapy No 209 (43.8 %) 268 (56.2 %) 0.8369
Yes 10 (40 %) 15 (60 %)
Clinical Stage I 4 (57.1 %) 3 (42.9 %) 0.2494
II 9 (36 %) 16 (64 %)
III 51 (52 %) 47 (48 %)
IV 153 (42.5 %) 207 (57.5 %)
Site Larynx 51 (45.5 %) 61 (54.5 %) 0
Lip/Oral Cavity 9 (11 %) 73 (89 %)
Other 17 (43.6 %) 22 (56.4 %)
Pharynx 142 (52.8 %) 127 (47.2 %)
Treatment Type CCRT 180 (58.1 %) 130 (41.9 %) 0
CCRT/ND 0 (0 %) 9 (100 %)
ICT/CCRT 20 (34.5 %) 38 (65.5 %)
Surg/CCRT 19 (15.2 %) 106 (84.8 %)

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Jun 2, 2025 | Posted by in ONCOLOGY | Comments Off on Prophylactic gastrostomy tube during chemoradiation for head and neck cancer decreases weight loss but increases rate of tube use beyond six months

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