S100, osteocalcin, osteonectin, androgen receptors, SATB-2, pan-cytokeratin [1, 2].

Osteocalcin is a non-collagenous calcium-binding protein synthesized by osteoblasts involved in the mineralization of bone tissue and dentin. It is expressed by osteoblasts in the bone and dentin. Osteocalcin is a specific marker for bone and osteogenic tumors.

Osteonectin is a calcium-binding bone matrix glycoprotein involved in the early mineralization steps of bone tissue. It is highly expressed in activated osteocytes. It is also expressed to a lesser degree in other cell types such as fibroblasts, endothelial cells, chondrocytes, and some epithelial types; consequently, osteonectin has a high sensitivity but low specificity for bone tissue and bone tumors and must be a part of antibody panel.