Lymphoma II: Hodgkin lymphoma

Aetiology and epidemiology

Hodgkin lymphoma is characterized by the presence of Reed–Sternberg cells within the neoplastic tissue (Fig 32.1a). It is more prevalent in males than in females (M : F ratio is 1.5–2.0 : 1) and has a peak incidence in age range 15–40 years. The cause is not known, but Epstein–Barr virus infection may be a cofactor.

Histological classification

This is well defined and of prognostic significance (Box 32.1). Reed–Sternberg (RS) cells are usually outnumbered by a non-malignant reactive infiltrate of eosinophils, plasma cells, lymphocytes and histiocytes. The RS cells are CD30+ (Fig. 32.1b); HL is of B-cell origin. The (classic) disease is classified histologically into mixed cellularity, nodular sclerosis, lymphocyte rich and lymphocyte depleted (Box 32.1). Prognosis for lymphocyte-rich HL is favourable, whereas lymphocyte-depleted HL is less favourable.

Box 32.1 Histological classification of Hodgkin lymphoma

Hodgkin lymphoma

Nodular lymphocyte predominant Hodgkin lymphoma

Classic Hodgkin lymphoma

Nodular sclerosis


Mixed cellularity


Jun 12, 2016 | Posted by in HEMATOLOGY | Comments Off on Lymphoma II: Hodgkin lymphoma

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