in Patients with Rheumatoid Arthritis and Osteoarthritis


Parameter

Group

EO

EC

BF

R (mm)

Controls

2.0

1.9

2.3 #,$

(1.7–2.6)

(1.6–2.6)

(1.8–2.8)

OA

2.7**

2.8***

3.2***,##

(2.4–3.4)

(2.2–3.8)

(2.5–4.1)

RA

2.6**

2.8**

3.3***,###,$$

(2.1–3.4)

(2.1–3.4)

(2.7–4.1)

A (cm2)

Controls

139

130

165 ###,$

(97–185)

(99–212)

(107–231)

OA

178*

222**,+

283***,###

(138–250)

(141–367)

(192–406)

RA

186**

236***,++

296***,###,$$$

(144–240)

(160–302)

(182–508)

LRL (mm)

Controls

111

115 ++

117 ##

(96–123)

(103–127)

(104–131)

OA

110

114 +++

149*,###,$$

(95–123)

(101–133)

(110–194)

RA

114

122 ++

149***,###,$$$

(99–129)

(107–149)

(116–213)

FBL (mm)

Controls

147

176 +++

173 ###

(129–170)

(150–210)

(144–216)

OA

166

205*,+++

212 ###,$

(138–209)

(162–297)

(162–247)

RA

176***

230***,+++

225**,###

(157–212)

(186–284)

(180–265)

TL (mm)

Controls

210

238 +++

234 ###

(189–238)

(202–272)

(208–281)

OA

221

279 +++

285*,###

(192–280)

(215–349)

(246–368)

RA

245**

286**,+++

297***,###,$

(206–284)

(248–346)

(248–418)

BF (%)

Controls



97

(93–99)

OA



88***

(77–94)

RA



87***

(77–92)


R sway radius, A developed area, LRL left-right length, FBL forward-backward length, TL total length, BF biofeedback coordination

*p < 0.05, **p < 0.005, ***p < 0.0005 for patients vs. controls (Mann-Whitney U test)

+p < 0.05, ++p < 0.005, +++p < 0.0005 for eyes open vs. eyes closed condition (Wilcoxon test)

#p < 0.05, ##p < 0.005, ###p < 0.0005 for eyes open vs. biofeedback condition (Wilcoxon test)

$p < 0.05, $$p < 0.005, $$$p < 0.0005 for eyes open vs. biofeedback condition (Wilcoxon test)



Figure 1 presents the raw recordings of posturogram trajectories in an RA patient in the EO, EC, and BF conditions. This patient exhibited larger sways in the EC condition compared with the EO and BF conditions.

A328041_1_En_29_Fig1_HTML.gif


Fig. 1
Representative trajectories of a rheumatoid arthritis patient in eyes open (EO), eyes closed (EC), and biofeedback coordination (BFC) tests

Table 2 and Fig. 2 demonstrate the results of receiver operating characteristic (ROC) curves in rheumatic patients. LRL motions in the EO, EC, and BF tests resulted in larger area under the curve (AUC) values than other motions did, but the maximum of AUC (>0.75) has been obtained for the BFC parameter. The sensitivity and specificity above 0.75 was achieved when the cut-off point of BFC equaled 92 %.


Table 2
Area under curve (AUC) values of ROC analysis


















Parameter

Patients

EO test

EC test

BF test

R

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Oct 9, 2016 | Posted by in ONCOLOGY | Comments Off on in Patients with Rheumatoid Arthritis and Osteoarthritis

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