Chapter 14 • Cancer remains a major cause of mortality among patients with primary and acquired immunodeficiencies. • Cancer in immunocompromised hosts is frequently associated with infectious agents, including the following: • Categories of genetic immunodeficiencies with increased risk of the development of cancer include the following:
Immunodeficiency and Cancer
Summary of Key Points
Epstein-Barr virus (associated with lymphoproliferative disorders and leiomyosarcoma)
Human papillomavirus (associated with skin anal and cervical carcinomas)
Combined defects with T-cell dysfunction (e.g., severe combined immunodeficiency or Wiskott-Aldrich syndrome)
Defects that inhibit lymphoid apoptosis (e.g., autoimmune lymphoproliferative syndrome)
Defects of genomic instability (e.g., ataxia telangiectasia)
Acquired deficiencies in T-cell immunity with increased risk of developing cancer, such as:Related posts:
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Immunodeficiency and Cancer
