This article focuses on clinical applications of T cells transduced to express recombinant T cell receptor and chimeric antigen receptor constructs directed toward hematological malignancies, and considers newer strategies incorporating gene-editing technologies to address GvHD and host-mediated rejection. Recent data from clinical trials are reviewed, and an overview is provided of current and emerging manufacturing processes; consideration is also given to new developments in the pipeline.
Key points
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T cells engineered with chimeric antigen receptors mediate high levels of leukemic remission.
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Emerging gene editing techniques are now being incorporated.
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Challenges for dissemination to a larger number of patients are being addressed.
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Gene Editing
In Vivo Hematopoietic Stem Cell Transduction
Therapeutic Gene Editing Safety and Specificity
Gene Therapy Approaches to Immunodeficiency
Hematopoietic Gene Therapies for Metabolic and Neurologic Diseases
Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases
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