© Springer Nature Singapore Pte Ltd. 2017
Saravana Kumar and Rachel Maria Gomes (eds.)Bariatric Surgical Practice Guide10.1007/978-981-10-2705-5_1414. Gallstone Disease Before and After Bariatric Surgery
(1)
Bariatric Division, Upper Gastrointestinal Surgery and Minimal Access Surgery Unit, GEM Hospital and Research Centre, Coimbatore, India
14.1 Introduction
Prevalence of gall stones in the general population is 5–10 % and among them 30 % need surgery subsequently for symptomatic disease. Obese patients are at increased risk for biliary disease [1]. The prevalence of gallstones in the obese is 13.6–47.9 % [1, 2]. Ultrasonogram (USG) is the most sensitive investigation for diagnosis of GSD but its use in obese individuals is limited due to increased adipose tissue mass. In obese individuals USG may miss 8–12 % gall stones [2]. There is an increased incidence of gall stone disease after bariatric surgery associated with the rapid weight loss period [3].
14.2 Cholelithiasis in Obesity
Bile secretion results from the active transport of solutes into the canaliculus followed by passive flow of water. The major organic solutes are bilirubin, bile salts, phospholipids and cholesterol. Water constitutes approximately 85 % of the volume of bile.
Bilirubin is conjugated with glucuronic acid by glucuronyl transferase and is excreted actively into the adjacent canaliculus. Bile salts are steroid molecules synthesized by the hepatocyte. The primary bile salts, cholic and chenodeoxycholic acid, account for more than 80 % of those produced. They are then conjugated with either taurine or glycine, can undergo bacterial alteration in the intestine to form the secondary bile salts, deoxycholate and lithocholate. The purpose of bile salts is to solubilize lipids and facilitate their absorption. Phospholipids and cholesterol are synthesized in liver. The normal volume of bile secreted daily by the liver is 750–1000 ml.
Cholesterol is highly non polar and insoluble in bile. Key to maintaining cholesterol in solution is the formation of micelles, a bile salt-phospholipid-cholesterol complex. Cholesterol solubility depends on the relative concentration of cholesterol, bile salts and phospholipids. When cholesterol saturation index (lithogenic index) is greater than 1.0, cholesterol is supersturated and crystallization occurs. Gall stones are common in obesity because of elevated biliary cholesterol secretion, incremented nucleation factors, and impaired gallbladder contractility [4] In obese patients, cholesterol secretion is greatly increased without any absolute reduction in bile salt or phospholipid secretion unlike non-obese individuals who have decreased bile salt and phospholipid secretion [4].
14.3 Cholelithiasis After Bariatric Surgery
Incidence of gall stones increases after bariatric surgery. Probable causes for increased incidence are rapid weight loss, increased bile cholesterol saturation, increased gallbladder secretion of mucin and reduced gallbladder motility due to injury of the vagal nerve [3, 4]. Patients are transiently at risk for gall stone formation during active weight reduction phase, usually during the first 6–12 months and the risk is very less after 2 years [3, 4]. Gustafsson et al. found that crystallization promoting compounds like mucin are of great importance in the development of cholesterol crystals and gallstones in obese subjects during weight reduction, probably because of defective gallbladder emptying [5].
Incidence differs among various types of bariatric surgeries. Incidence of gallstones is reported to be 26.5 % in gastric banding patients though only 6.8 % of patients become symptomatic postoperatively [6]. Asymptomatic gallstones ranged from 30 to 52.8 % after 6 to 12 months postoperatively whilst symptomatic gallstones occurred in 7–16 % of roux-en-Y gastric bypass (RYGB) patients [7–11]. Coupaye et al. found out that the incidence of cholelithiasis after sleeve gastrectomy (SG) and RYGB were similar (28 % Vs 34 %) with most cases occurring in first year and 12 % and 13 % of patient who underwent SG & RYGB, respectively, became symptomatic [12].
Coupaye et al. identified weight loss of >30 kg at 6 months as a risk factor for post-operative cholelithiasis [12]. Melmer et al. followed up 190 patients over 10 years after bariatric surgery and identified female sex and rapid weight loss as major risk factors for post-operative cholelithiasis [7]. Frequency was highest in the first 6 months but declined over time to <1 % per year after 3 years. An excess weight loss of >25 % within the first 3 months was the strongest predictor [8]. Similar results were shown by Li et al. who concluded that a weight loss of more than 25 % of original weight was the only factor that help selecting patients for post-operative USG surveillance and subsequent cholecystectomy once gallstones were identified [13].
14.4 Cholecystectomy in Obese Patients
Cholecystectomy in patients undergoing bariatric surgery is a controversial area with lots of ongoing debate. There is no uniform consensus among surgeons regarding the optimal management strategies. Traditionally cholecystectomy was indicated only in the presence of both gallstones and symptoms, but some surgeons have advocated cholecystectomy even in the absence of symptoms and sometimes even in the absence of gallstones [14].
Cholecystectomy in patients undergoing bariatric surgery is technically demanding due to suboptimal port placement and difficult body habitus [3]. It is also less popular with some surgeons due to increased operative time (adds ~18 min to laparoscopic roux-en-Y gastric bypass (LRYGB)), morbidity, prolonged hospitalization and surgeons concern of removing a normal organ if preoperative investigation shows no cholelithiasis [3, 4]. Serious complications can occur in 2–3 % of patients [3].
The various strategies for management include a prophylactic approach, an elective/selective approach and a conventional approach which is discussed below.
14.4.1 Prophylactic Approach
This approach refers to performing laparoscopic cholecystectomy in all patients at the time of initial surgery, regardless of the presence or absence of gallstones [3]. The rationale behind this approach is based on the increased incidence of gallstones after bariatric surgery compared to the normal population and the low sensitivity and specificity of USG in morbid obesity [14]. The main concern is that the diagnosis of microlithiasis is difficult and incidence might be higher than expected [4].
This is supported by the findings of Fobi et al. who found abnormal findings in gall bladder specimens including gall stones, cholesterolosis and cholecystitis in 75 % of surgical specimens despite negative pre-operative USG. He reported additional time of 15 min with no specific morbidity [2]. Similarly Nougou et al. found some pathology in almost 82 % of specimens with additional 19 min for lap cholecystectomy and no specific morbidity related to it [15]. Liem et al. found gallbladder pathology in 80 % specimens [16]. Guadalajara et al. found gallstones in 24 % of the specimens while pre-operative USG was positive for stones in only 16 % [17]. Obeid et al. did a study to assess the safety of laparoscopic adjustable gastric banding with concurrent cholecystectomy for symptomatic cholelithiasis and found that it is as safe as laparoscopic adjustable gastric banding (LAGB) alone [8].
14.4.2 Elective/Selective Approach
This approach involves performing simultaneous laparoscopic cholecystectomy only in patients with gallstones diagnosed pre/intra-operatively, even if asymptomatic [3, 14]. The rationale behind this is an assumed higher incidence of symptomatic disease as compared to patients without gallstones.
Hamad et al. performed simultaneous cholecystectomy in 16.9 % patients during RYGB and compared outcomes in those who did not have concomitant surgery. These had significantly longer operative time, longer hospital stay and higher major morbidity. There was however no specific morbidity directly related to cholecystectomy [18]. In the series of open gastric bypass of Caruana et al., cholecystectomy was performed after the diagnosis of gallstones by intraoperative palpation of the gallbladder with no significant increase in morbidity but with longer operative time [19]. Ahmed et al. in his series of 400 patients found significant increase in operative time of 29 min with no additional morbidity [20].
Villegas et al. performed simultaneous cholecystectomy on 14 % of patients after intraoperative diagnosis of gallstones or sludge with the aid of laparoscopic ultrasound and patients were adviced prophylactic ursodeoxycholic acid at discharge. On follow up there was a low incidence of symptomatic gallstones requiring cholecystectomy after LRYGB and they concluded that selective cholecystectomy with close patient follow-up is a rational approach [21]. Nagem et al. prospectively followed LRYGB patients and found that 28.9 % patients developed gallstones and 15.8 % patients developed symptoms (biliary pain, acute biliary pancreatitis) [4]. They concluded that it is reasonable to perform cholecystectomy during RYGB in the presence of cholelithiasis or if gallstones develop after the procedure. Thus this approach reduces the potential for future gallbladder-related morbidity and the need for further surgery. Hence this can be a preferred option for patients with simultaneous gallstone disease whether symptomatic or asymptomatic.