ENDOMETRIUM (ICD‐O‐3 C54.0, 1, 3, 8, 9, C55)

UTERUS ENDOMETRIUM (ICD‐O‐3 C54.0, 1, 3, 8, 9, C55)

The definitions of the T, N, and M categories correspond to the FIGO stages. Both systems are included for comparison.

Rules for Classification

The classification applies to endometrial carcinomas and carcinosarcomas (malignant mixed mesodermal tumours). There should be histological verification with subdivision by histological type and grading of the carcinomas. The diagnosis should be based on examination of specimens taken by endometrial biopsy.

The FIGO stages are based on surgical staging. TNM stages are based on clinical and/or pathological classification.

Anatomical Subsites (Fig. 424)

  1. Isthmus uteri (C54.0)
  2. Fundus uteri (C54.3)
  3. Endometrium (C54.1)

Regional Lymph Nodes (Fig. 425)

The regional lymph nodes are the pelvic (hypogastric [obturator, internal iliac] (3), common (5) and external (4) iliac, parametrial (2), and sacral (6)) and the para‐aortic nodes (7).

TNM Clinical Classification

T – Primary Tumour

FIGO Stages Definition
Primary tumour cannot be assessed
No evidence of primary tumour
T1 I* Tumour confined to the corpus uteri1 (Fig. 437)
 T1a  IA*  Tumour limited to the endometrium or invading less than half of myometrium
 T1b  IB  Tumour invades one half or more of myometrium
T2 II Tumour invades cervical stroma, but does not extend beyond the uterus2 (Fig. 438)
T3 III Local and/or regional spread as specified below
 T3a  IIIA  Tumour invades the serosa of the corpus uteri or adnexae (direct extension or metastasis) (Fig. 439)
 T3b  IIIB  Vaginal or parametrial involvement (direct extension or metastasis) (Fig. 439)
 N1  IIIC  Metastasis to pelvic or para‐aortic lymph nodes (Fig. 441)

  IIIC1   Metastasis to pelvic lymph nodes

  IIIC2   Metastasis to para‐aortic lymph nodes with or without metastasis to pelvic lymph nodes
T4M1 IVAIVB Tumour invades bladder/bowel mucosa3 (Fig. 440)Distant metastasis

1Endocervical glandular involvement only should now be considered as stage I.

2Positive cytology has to be reported separately without changing the stage.

3The presence of bullous oedema is not sufficient evidence to classify as T4.

Schematic illustration of tumour confined to the corpus uteri.

Fig. 437

Schematic illustration of tumour invades cervical stroma, but does not extend
beyond the uterus.

Fig. 438

Schematic illustration of Vaginal or parametrial involvement.

Fig. 439

Schematic illustration of Metastasis to pelvic or para-aortic lymph nodes.

Fig. 440

Schematic illustration of tumour invades bladder or bowel mucosa.

Fig. 441

N – Regional Lymph Nodes

NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Pelvic lymph node metastasis
N2 Para‐aortic lymph node metastasis

M – Distant Metastasis

M0 No distant metastasis
M1 Distant metastasis (excluding metastasis to vagina, pelvic serosa, or adnexa, including metastasis to inguinal lymph nodes, intra‐abdominal lymph nodes other than para‐aortic or pelvic nodes)

pTNM Pathological Classification

The pT and pN categories correspond to the T and N categories.

pM1 Distant metastasis microscopically confirmed

pM0 and pMX are not valid categories.

pN0 Histological examination of a pelvic lymphadenectomy specimen will ordinarily include 6 or more lymph nodes. If the lymph nodes are negative, but the number ordinarily examined is not met, classify as pN0.


Dec 15, 2022 | Posted by in ONCOLOGY | Comments Off on ENDOMETRIUM (ICD‐O‐3 C54.0, 1, 3, 8, 9, C55)
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