Effectiveness Research for Sarcoma

 

Outcome

Clinical area

Local recurrence/overall survival

Quality of life

Cost

Multidisciplinary consultation

?

NA

?

Guideline oriented care

?

NA

Lower

Regionalization of sarcoma care

Improved

Improved

?

Soft tissue extremity sarcoma

Neoadjuvant chemotherapy

Not improved

Similar

?

Neoadjuvant chemoradiation

Not improved

Similar

?

Adjuvant chemotherapy

Modest improvement in selected patients

?

?

Adjuvant radiation

Improved local control

Worse

Higher

Neoadjuvant radiation

Equivalent local control

Improved

?

Brachytherapy

Improved local control

?

?

Radiation modality

?

?

?

Surgery for local recurrence

Improved

?

?

Retroperitoneal sarcoma

Preoperative biopsy

NA

NA

?

Radical compartment surgery

?

?

?

Radiation

?

?

?

Surveillance

?

?

?





References



1.

NCCN clinical practice guidelines in oncology (NCCN)—soft tissue sarcoma 2013. Available at www.​nccn.​org


2.

Wasif N, Tamurian RM, Christensen S et al (2012) Influence of specialty and clinical experience on treatment sequencing in the multimodal management of soft tissue extremity sarcoma. Ann Surg Oncol 19(2):504–510CrossRefPubMed


3.

Wasif N, Smith CA, Tamurian RM et al (2013) Influence of physician specialty on treatment recommendations in the multidisciplinary management of soft tissue sarcoma of the extremities. JAMA Surg 148(7):632–639CrossRefPubMed


4.

Ray-Coquard I, Thiesse P, Ranchere-Vince D et al (2004) Conformity to clinical practice guidelines, multidisciplinary management and outcome of treatment for soft tissue sarcomas. Ann Oncol Official J Eur Soc Med Oncol/ESMO 15(2):307–315CrossRef


5.

Jansen-Landheer ML, Krijnen P, Oostindier MJ et al (2009) Improved diagnosis and treatment of soft tissue sarcoma patients after implementation of national guidelines: a population-based study. Eur J Surg Oncol J Eur Soc Surg Oncol Brit Assoc Surg Oncol 35(12):1326–1332


6.

Bagaria SP, Ashman JB, Daugherty LC et al (2014) Compliance with national comprehensive cancer network guidelines in the use of radiation therapy for extremity and superficial trunk soft tissue sarcoma in the United States. J Surg Oncol 109(7):633–638CrossRefPubMed


7.

Perrier L, Buja A, Mastrangelo G et al (2012) Clinicians’ adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions. BMC Health Serv Res 12:82CrossRefPubMedCentralPubMed


8.

Gutierrez JC, Perez EA, Moffat FL et al (2007) Should soft tissue sarcomas be treated at high-volume centers? An analysis of 4205 patients. Ann Surg 245(6):952–958CrossRefPubMedCentralPubMed

Oct 1, 2016 | Posted by in ONCOLOGY | Comments Off on Effectiveness Research for Sarcoma

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