Definition of Outcomes After Bariatric Surgery







 

  • 3.


    Percentage of total weight loss (%TWL):




    
$$ \%\mathrm{T}\mathrm{W}\mathrm{L} = \frac{\mathrm{Initial}\ \mathrm{W}\mathrm{eight} - \mathrm{Postoperative}\ \mathrm{W}\mathrm{eight}}{\mathrm{Initial}\ \mathrm{W}\mathrm{eight}}\times 100 $$

     

  • 4.


    Percentage of excess BMI loss (%EBMIL):




    
$$ \%\mathrm{EBMIL} = \frac{\varDelta \mathrm{B}\mathrm{M}\mathrm{I}}{\left(\mathrm{Initial}\ \mathrm{B}\mathrm{M}\mathrm{I} - 25\right)}\times 100 $$
    and/or

     

  • 5.


    Percent excess weight loss (%EWL):




    
$$ \%\mathrm{E}\mathrm{W}\mathrm{L} = \frac{\ \mathrm{Initial}\ \mathrm{W}\mathrm{eight} - \mathrm{Postoperative}\ \mathrm{W}\mathrm{eight}}{\left(\mathrm{Initial}\ \mathrm{W}\mathrm{eight}-\mathrm{Ideal}\ \mathrm{Body}\ \mathrm{W}\mathrm{eight}\right)}\times 100 $$

     






      5.2.2 Percentile Charts


      Van de Laar recommended percentile-based charts based on large numbers of patients from multiple surgeons and centres with essentially good follow-up data [5]. He implied that percentile charts are neutral and can be based on different characteristics such as gender, age or baseline BMI. However these percentile charts are scarcely found in the literature.


      5.2.3 Body Fat Parameters


      The relationship between BMI and mortality is U-shaped and hence believed that body fat mass is a better measurement of outcomes. The use of BMI as a proxy for the measurement of adiposity can be misleading as body weight is the sum of individual organs and tissues including adipose tissue, skeletal muscle mass and organ mass. In addition, BMI does not convey any information on fat distribution in the body [6].

      Bioelectric Impedence Analysis (BIA) is one of the available direct measurements of body fat [79]. Clinical studies have validated foot-to-foot BIA technology for body composition analysis [10]. National norms for BIA differences between ethnic and racial groups based on NHANES111 have been published recently. Studies on fat mass show a direct linear relationship between body fat and all-cause mortality [11].



      5.3 Co Morbidities Outcomes


      The metabolic effects from weight loss should also be considered in defining success of bariatric surgery. Now that metabolic benefits of bariatric surgery are well recognized, bariatric success should be redefined to include the metabolic parameters [5]. It is well documented that small amounts of weight loss carry significant health benefits and perhaps individual co-morbid conditions should be measured as parameters of successful outcomes following bariatric surgery. These should importantly include type 2 diabetes, dyslipidemia and hypertension.


      5.3.1 Type 2 Diabetes


      Several studies have detailed the improvement in diabetes as a result of both restrictive and malabsorptive bariatric surgery. Pories published in 1995 about the effectiveness of LRYGB on the treatment of diabetes [12]. Many studies have followed substantiating the effectiveness of bariatric surgery on diabetes and hence this should be a powerful measurement of outcomes following bariatric surgery. For reporting outcomes in diabetes, Brethauer et al. recommended the following glycemic definitions for standardization [4]:


      Definitions of glycemic outcomes after bariatric surgery


























      Outcome

      Definition

      Remission (complete)

      Normal measures of glucose metabolism (HbA1c <6 %, FBG <100 mg/dL) in the absence antidiabetic medications

      Remission (partial)

      Sub-diabetic hyperglycemia (HbA1c 6–6.4 %, FBG 100–125 mg/dL) in the absence antidiabetic medications

      Improvement

      Statistically significant reduction in HbA1c and FBG not meeting criteria for remission or decrease in antidiabetic medications requirement (by discontinuing insulin or one oral agent or 1/2 reduction in dose)

      Unchanged

      The absence of remission or improvement as described above

      Recurrence

      FBG or HbA1c in the diabetic range (≥126 mg/dL and ≥6.5 %, respectively) or the need for antidiabetic medication after any period of complete or partial remission


      Glycosylated hemoglobin (HbA1c), fasting blood glucose (FBG)

    1. Nov 18, 2017 | Posted by in ENDOCRINOLOGY | Comments Off on Definition of Outcomes After Bariatric Surgery

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