Colonoscopy and Cardiovascular System


Low risk <1 %

Moderate risk 1–5 %

High risk >5 %

Endoscopy procedures

Breast

Dental

Endocrine

Eye

Gynaecology

Reconstructive

Orthopaedic – minor (knee surgery)

Urologic – minor

Abdominal

Carotid

Peripheral arterial angioplasty

Endovascular aneurism repair

Head and neck surgery

Neurological/orthopaedic major (hip and spine surgery)

Pulmonary, renal/liver transplantation

Urologic – major

Aortic and major vascular surgery

Peripheral vascular surgery



Determination of functional capacity is a highly important step in evaluation of preoperative cardiac risk. If patient’s recent exercise test is unavailable, functional capacity can be easily estimated by questioning daily life activities in patient’s history [4]. Functional capacity is measured in metabolic equivalents (METs). One MET is equal to basal metabolic rate. Considering that 1 MET stands for the metabolic requirement at rest, 4 METs are needed for climbing two flights of stairs whereas for challenging sports that require some effort such as swimming, more than 10 METs is needed (Table 3.2). Perioperative cardiac risk increases in the patients whose functional capacity is below 4 METs.


Table 3.2
Approximate energy requirements for various activities. MET: Metabolic Equivalent















1 MET

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Meeting the daily life requirements by oneself (eating, getting dressed, going to bathroom)

Going around indoors

Short distance walking on straight road

4 MET

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Going up a hill or climbing two flights of stairs

Short-distance jogging

General housework (wiping the floors, moving items)

>10 MET

Long-distance jogging

Demanding sports (swimming, basketball, football)

Evaluation of patient’s preoperative risk factors is highly important in terms of cardiac complications that might occur during and after a colonoscopic procedure. The physician who conducts the procedure must watch out for a cardiac event in patients with coronary artery disease history or patients without coronary artery disease history but a high risk. During or after the procedure, acute coronary syndrome might develop in the patient. The endoscopist should have knowledge of acute coronary syndrome to diagnose and, in case of doubt, consultation with a cardiologist is essential. Acute coronary syndromes are myocardial perfusion disrupting disease groups which generally develops on atherosclerotic coronary artery disease base and characterized by short-term occlusion in coronary arteries. It is an acute urgent case, having risk of progress into myocardial infarction or cardiac death (Figs. 3.1 and 3.2). In suspicion of acute coronary syndrome regarding urgent medical treatment and revascularization strategies, a cardiologist opinion should be obtained.

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Fig. 3.1
Classification of acute coronary syndrome. STEMI (ST elevated MI), NSTEMI (non ST elevated MI)


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Fig. 3.2
ST elevated MI/non ST elevated MI – unstable angina


Endoscopy-Related Factors Leading to Acute Coronary Syndrome


There are various factors that increase cardiac stress during endoscopy procedures [5]:



  • Autonomic nervous system

    Tachycardia, myocardial ischaemia and cardiac arrhythmia might occur in consequence of activation of the sympathetic nervous system. Increase in parasympathetic activity is at the forefront in colonoscopy, and bradycardia, hypotension and syncope attacks might be encountered.


  • Procedure-related mechanic stress

    Fluctuations in cardiac rhythm might be seen particularly during the insufflation of the colon.


  • Anxiety and neuroendocrine stress response

    It is demonstrated that the serum catecholamine, cortisol, glucose levels are raised before and after procedure.


  • Sedation and analgesia

    In a study, 94 % of the cardiorespiratory events during the endoscopy were attributed to sedation [6]. Furthermore, there is no systematic study showing that sedation lowers haemodynamic stress in patients at risk. Even if the oxygen saturation is normal, apnoea and hypopnoea periods were shown by end-tidal CO2 measurements. Confidence interval of Propofol is particularly narrow and vasodilator effect is present. For these reasons, it might cause complications in elderly, comorbid and hypovolemic patients. It is vital to choose the anaesthetic agents to be used during colonoscopy, according to patient’s evaluation of cardiovascular risks. Cardiopulmonary events were experienced frequently in case of high-dose Meperidine usage while the event incidence was inversely proportional in case of Fentanyl and Midazolam usage [7]. QT extension and Torsade de Pointes are among the complications of Droperidol which is used in conscious sedation for particularly challenging endoscopy procedures. However, in a study, no relation was detected between Droperidol usage in conscious sedation and rise in cardiopulmonary event [7]. It is suggested to avoid analgesic agents (Morphine, Droperidol, barbiturates) that could induce hypertension in patients with heart failure, severe stenosis and tachyarrhythmia.


Essential Investigations for Preoperative Cardiac Evaluation



Electrocardiography (ECG)


ECG should be requested for patients who have angina or coronary event history in last 2 months, arrhythmia history, diabetes mellitus (DM) for asymptomatic patients older than 45 for males and 55 for females who have two and more risk factors. Nevertheless, ECG should not be ordered routinely for asymptomatic patients who do not fit these criteria.


Echocardiography


It can be obtained in patients with decompensated congestive heart failure symptoms and in case of detected murmur and prior CHF (congestive heart failure) history. Otherwise, routine echocardiography request is class 3 [8].


Stress Test


Exercise stress test can be obtained in case of coronary artery disease or revascularization history in presence of angina complaints and it can be obtained in moderate or high-risk patients whose basal ECG is normal. Myocardial perfusion scintigraphy can be ordered for the patients with left bundle branch block, poor effort capacity and respiratory diseases.


Coronary Angiography


Electively planned operation should be postponed for patients who show high risk at stress test, whose angina continues despite the medical treatment and who has high risk for coronary artery disease, and coronary angiography should be proposed.


Regulation of Medication Increasing Tendency to Preoperative Bleeding



Antiaggregant Medications


Aspirin therapy is generally discontinued in perioperative period since it is considered to increase haemorrhagic complications. A large-scale meta-analysis of 41 studies comparing the bleeding risks of continuation to discontinuation of aspirin in perioperative period was conducted in 49,590 patients. As a result of this analysis, it is determined that risk of bleeding complication increased 1.5 times but aspirin did not cause more severe bleeding complications [9]. Systematical analysis of patients at risk and patients who have ischaemic heart disease demonstrated three times more increase in risk of major adverse cardiac event with discontinuation of aspirin therapy (odds ratio (OR) = 3,14, %95 confidence interval (CI) 1,8-5,6). Aspirin therapy should be discontinued only if bleeding risk is more than the cardiac benefit. Before minor surgical or endoscopic procedures, a careful evaluation about discontinuation of antithrombotic medications should be carried out. Principally, when individual risk and benefit assessment is taken into consideration, patients who get antiplatelet therapy do not have to stop their medication before aforementioned interventions. Platelet transfusion or use of other prohemostatic medications is recommended for patients who receive antiplatelet therapy such as Acetylsalicylic acid, Ticlopidine, Clopidogrel; for Prasugrel or Ticagrelor users and patients who have excessive or life-threatening perioperative bleeding. The decision-making on discontinuing antiplatelet therapy or not is hardest for the patient group who had previous cardiac revascularization procedure and received dual antiplatelet therapy. In percutaneous revascularization-applied patients, one of the antiplatelet therapies is stopped and treatment continues with acetylsalicylic acid ideally after 3 months and 12 months for bare metal stent-inserted ones and drug-eluting stent-inserted ones, respectively. It is suggested that the elective procedures should be postponed within these periods and performed afterwards under acetylsalicylic acid therapy [10, 11].

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Nov 17, 2016 | Posted by in ONCOLOGY | Comments Off on Colonoscopy and Cardiovascular System

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