ACTH Stimulation Test for Late Onset (Nonclassic) 21-Hydroxylase Deficiency






Assay for 17 OHP:

Radioimmunoassay (RIA) .


Interpretation:

With late onset 21-hydroxylase deficiency, the absolute value of 17-hydroxyprogesterone at 60 min sample is > 10 ng/dl [2, 3].


Caveats:





  • Baseline androgen levels return to baseline after 8 weeks of discontinuation of oral contraceptive pills (OCP) [4].


  • There is not enough data in regards to the effect of OCP on 17 OHP levels after ACTH stimulation.


Procedure:

Completed as outpatient.



1.

Obtain baseline blood sample for (17 OHP) and cortisol.

 

2.

Give cortrosyn 250 mcg IM.

 

3.

At 60 min, obtain sample for (17 OHP) and cortisol.

Only gold members can continue reading. Log In or Register to continue

Related posts:

Default ThumbnailMetyrapone Stimulation Test Default ThumbnailOvine Corticotropin-Releasing Hormone (oCRH) Stimulation Test Default ThumbnailThyroid Cancer Follow-Up: Thyrogen Injection with No Scan Default ThumbnailClonidine Suppression Test Default ThumbnailIntravenous Saline Suppression Test Levothyroxine Absorption Test

Stay updated, free articles. Join our Telegram channel
Tags:
Sep 18, 2016 | Posted by in ENDOCRINOLOGY | Comments Off on ACTH Stimulation Test for Late Onset (Nonclassic) 21-Hydroxylase Deficiency

Full access? Get Clinical Tree
Get Clinical Tree app for offline access