♦Pentostatin

(pen’-toe-stah-tin)

Nipent

Pregnancy Category D

Mechanism of Action

An antitumor antibiotic that inhibits the ADA enzyme and causes cell lysis.

Indications

Alpha-interferon-refractory hairy cell leukemia in adults.

Metabolism/Excretion

Metabolized in the liver; excreted in urine.

Dosage Range

♦ Adult: 4 mg/m² IV every other week.

♦ Pediatric: Safety and effectiveness not established.

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Jul 20, 2016 | Posted by drzezo in ONCOLOGY | Comments Off