Classification: ICD-9 088.0; ICD-10 A44
Syndromes and synonyms: Oroya fever, Carrión disease, verruga peruana (Peruvian wart).
Agent: Bartonella bacilliformis, a fastidious intracellular Gram- negative bacterium.
Reservoir: Humans are the only known reservoir host.
Vector: The sandfly Lutzomyia verrucarum. Preferred habitat: narrow river gorges at elevations between 500 and 3,200 meters.
Transmission: By bite of the female sandfly (usually at dusk and at sundown, often indoors); rarely by blood transfusion or transplacental. There is no direct person-to-person transmission.
Cycle: Human–sandfly–human. Humans can be bacteremic for many months. Period of infectivity in the sandfly is unknown.
Incubation period: 16–22 days, occasionally up to 7 months.
Clinical findings