♦Tretinoin
(tret’-i-noyn)
Retinoic acid, Vesanoid
Pregnancy Category D
Mechanism of Action
Not understood. This natural retinoid may play a role in hematopoiesis and immune function. Inhibits the proliferation of acute promyelocytic leukemia.
Indications
Acute promyelocytic leukemia.
Metabolism/Excretion
Metabolized in the liver; excreted in urine and feces.
Dosage Range
♦ Adult: 45 mg/m2 per day PO in two divided doses. Discontinue 30 days after remission is obtained or after 90 days.
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