♦Thioguanine
(thye-oh-gwah’-neen)
TG, 6-thioguanine, Tabloid
Pregnancy Category D
Mechanism of Action
An antimetabolite that inhibits purine synthesis by substituting for the nucleotide guanine. S phase-specific.
Indications
Acute lymphocyte leukemia, acute nonlymphocytic leukemia, chronic myelogenous leukemia.
Metabolism/Excretion
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