♦Streptozocin
(strep-toe-zoe’-sin)
Zanosar
Pregnancy Category C
Mechanism of Action
A nitrosourea alkylating agent that causes cell lysis by impairing DNA synthesis through intrastrand cross-linking of DNA.
Indications
Pancreatic carcinoma, colon carcinoma, carcinoid tumors.
Metabolism/Excretion
Metabolized in the liver; excreted in urine.
Dosage Range
♦ Adult: 500 mg/m2 per day IV for 5 days every 6 weeks or 1 g/m2 per week IV for 2 weeks; increase next doses if no toxicity or no response; maximum 1.5 g/m2 per week.
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