♦Plicamycin
(plye-kay-mye’-sin)
Mithramycin, Mithracin
Pregnancy Category X
Mechanism of Action
An antitumor antibiotic that binds to DNA and inhibits DNA-directed RNA synthesis. Acts on osteoclasts and blocks the action of parathyroid hormone.
Indications
Testicular carcinoma, hypercalcemia.
Metabolism/Excretion
Metabolized in the liver; excreted in urine.
Dosage Range
Adult
♦ Testicular carcinoma: 25 to 30 μg/kg per day for 8 to 10 days.
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