Cell cycle-nonspecific agent that interacts with DNA and inhibits the DNA enzyme topoisomerase, causing cell lysis.

Acute monocytic leukemia, acute myelocytic leukemia, acute promyelocytic leukemia.

Metabolized in the liver; primarily excreted in urine and feces.

♦ Adult: 12 mg/m² per day for 2 to 3 days in combination therapy with cytosine arabinoside 100 mg/m² continuous infusion for 5 to 7 days. Cumulative cardiac dose is 120 to 140 mg/m², depending on history of mediastinal radiation or anthracycline therapy.