♦Mitomycin

(mye-toe-mye’-sin)

Mutamycin, MTC, Mitomycin-C

Pregnancy Category D

Mechanism of Action

Cell cycle-nonspecific antitumor antibiotic that inhibits DNA, RNA, and protein synthesis, causing cell lysis.

Indications

Part of combination or palliative therapy for disseminated adenocarcinoma of the stomach or pancreas. Unlabeled uses: Ovarian, cervical, or breast carcinoma; head and neck cancer; and non-small cell lung cancer.

Metabolism/Excretion

Metabolized in the liver; primarily excreted in urine.

Dosage Range

♦ Adult: Initially, 20 mg/m² IV as a single dose through a functioning IV catheter. Re-evaluate the patient after each course; reduce the dose if any toxicity is experienced. The following dosage schedule may be used at 6- to 8-week intervals:

Leukocytes/mm³	Platelets	Percentage of Prior Dose to Be Given

>4000	>100,000	100%
>3000–3999	>75,000–99,999	100%
>2000–2999	>25,000–74,999	70%
<2000	<25,000	50%