♦Interferon-beta-1a
(in-ter-feer’-on)
Avonex
Pregnancy Category C
Mechanism of Action
Not clearly understood; exerts biologic activities by binding to cell surface receptors.
Indications
To decrease physical disability and reduce the frequency of clinical exacerbations in relapsing forms of multiple sclerosis.
Metabolism/Excretion
After IM injection, serum levels peak between 3 and 15 hours with an elimination half-life of 10 hours. After SQ injection, serum levels peak between 3 to 18 hours with an elimination half-life of 8.6 hours.
Dosage Range
♦ Adult: 30 mcg injected IM once a week.
♦ Pediatric: Safety and efficacy not established.
Drug Preparation/Stability