Floxuridine is a cytotoxic antimetabolite that acts primarily by interfering with the synthesis of DNA; to a lesser extent, it inhibits the formation of RNA.

Palliative management of GI adenocarcinoma metastatic to the liver (when given by regional intra-arterial infusion) for patients considered incurable by surgery or other means.

Metabolized in the liver; excreted in the urine; also expired as respiratory carbon dioxide. It has a biphasic half-life: initial = 10 to 20 minutes; terminal = 20 hours.

♦ Adult: 0.1 to 0.6 mg/kg per day. If is given by hepatic artery infusion, the dosage is 0.4 to 0.6 mg/kg per day because the liver metabolizes the drug, reducing systemic
toxicities. Therapy can continue when side effects have resolved and should be maintained as long as a therapeutic response is observed.