♦ Chronic renal failure: Initially, 50 to 100 units/kg three times a week. Reduce dose as the hematocrit approaches 36% or increases by more than 4 points in any 2-week period. Dosage is individualized to maintain the hematocrit in target range. Administer IV in dialysis patients; inject SQ or administer IV in patients not receiving dialysis. Unless clinically indicated, dosage adjustments should not be made more frequently than once a month. Maintenance dose is titrated to maintain hematocrit target range.

♦ HIV patients receiving zidovudine: Determine serum erythropoietin level before administration. Starting dose for patients with serum erythropoietin levels <500 mUnits/mL who are receiving <4,200 mg zidovudine per week: 100 units/kg as an IV infusion or SQ injection administered three times a week for 8 weeks. If desired response is not achieved after 8 weeks of therapy, increase by 50 to 100 units/kg three times a week. Maintenance dose is titrated to maintain hematocrit target range.