♦ Single agent: 360 mg/m² on day 1 given every 4 weeks. In general, the carboplatin dose should not be repeated until the neutrophil count is 2000/mm³ and the platelet count is ≥100,000/mm³.

♦ Combination with cyclophosphamide: 300 mg/m² on day 1 IV every 4 weeks.

♦ Formula dosing: Another method for calculating the initial carboplatin dose is the use of a mathematical formula based on the pre-existing renal function and desired platelet nadir. This approach takes into account the pre-treatment renal function, which might be overlooked using the formula based on body surface. The formula, proposed by Calvert, is as follows:

Total dose (mg) = (target AUC) × (glomerular filtration rate + 25)

AUC (area under the curve) is obtained by plotting the plasma level of a drug over time and measuring the area beneath the plotted curve. Glomerular filtration rate has a good correlation to creatinine clearance. Therefore, this value is used in the calculation for carboplatin. The target area under the curve of 4 to 6 mg/mL/ min using carboplatin as a single agent is often used.