♦Altretamine
(al-treh’-tah-meen)
Hexalen
Pregnancy Category D
Mechanism of Action
Unknown
Indications
♦ Palliative treatment for recurrent or persistent ovarian cancer after first-line therapy with cisplatin or alkylating agent; use as a single agent
♦ Lymphoma, lung cancer
Metabolism/Excretion
Undergoes rapid and extensive metabolism in the liver and is excreted by the kidneys. Half-life: 0.5 to 3.0 hours.
Dosage Range
♦ Adult: Given for 14 or 21 days in a 28-day cycle at a dosage of 260 mg/m2 per day. Therapy may be temporarily discontinued (for more than 14 days) and subsequently restarted at 200 mg/kg per day for any of the following: GI intolerance unresponsive to symptomatic measures; WBC count <2000/mm3 or granulocyte count <1000/mm3; platelet count <75,000/mm3; progressive toxicity.

Stay updated, free articles. Join our Telegram channel

Full access? Get Clinical Tree

